Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

Quantification of Ultrasound Contrast Agents Using High Frequency Ultrasound

Ultrasound contrast agents (UCAs) are small microbubbles filled with gas. Because of their scattering properties, UCAs enhance the diagnostic capabilities of ultrasonic imaging. UCAs are associated with therapeutic or enhancing therapeutic applications of ultrasound and with possible adverse bioeffects. Quantification of the in vivo concentration of microbubbles is therefore essential to establ...

High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes.

High-frequency ultrasound (HFUS) is widely employed as a non-invasive method for imaging internal anatomic structures in experimental small animal systems. HFUS has the ability to detect structures as small as 30 µm, a property that has been utilized for visualizing superficial lymph nodes in rodents in brightness (B)-mode. Combining power Doppler with B-mode imaging allows for measuring circul...

High Framerate Imaging of Ultrasound Contrast Agents

Phospholipid-coated ultrasound contrast agents may deflate or even collapse because of stress resulting from ultrasound-induced oscillations. In this work we investigate the behavior of isolated contrast agent microbubbles during prolonged ultrasound excitation. Isolated microbubbles placed in a thin capillary tube were excited with hundreds of ultrasound pulses at a low mechanical index, and t...

Dual-Frequency Piezoelectric Transducers for Contrast Enhanced Ultrasound Imaging

For many years, ultrasound has provided clinicians with an affordable and effective imaging tool for applications ranging from cardiology to obstetrics. Development of microbubble contrast agents over the past several decades has enabled ultrasound to distinguish between blood flow and surrounding tissue. Current clinical practices using microbubble contrast agents rely heavily on user training...

Acoustic characterisation of ultrasound contrast agents at high frequency